Recombinant Rat Calcitonin/CT protein (TRX, His tag)

Specifications

Catalog number

PDER100172-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Calcitonin is a secreted protein which belongs to the calcitonin family. Calcitonin is cleaved into the following two chains: Calcitonin and Katacalcin. Katacalcin is a potent plasma calcium-lowering peptide. Calcitonin is a 32-amino acid linear polypeptide hormone. Calcitonin acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH) . Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis. Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

Abbreviation

Calcitonin; CT

Synonyms

Calc; Calca; Calcitonin

UniProt

P01257

Accession Number

P01257

Expression System

E.coli

Tag

N-Trx-His

Sequence

Cys85-Pro116

Field of Research

Signal Transduction; Cardiovascular; Neuroscience; Cancer

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

23.4 kDa

Observed Molecular Weight

22 kDa

Species

Rat