Recombinant Rat ST14/Matriptase protein (His tag)

Specifications

Catalog number

PDER100225-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) . ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.

Abbreviation

ST14; Matriptase

Synonyms

Epithin; HAI; MTSP1; Membrane type serine protease 1; PRSS14; Prostamin; SNC19; ST14; Serine protease 14; TADG15; TMPRSS14

UniProt

Q9JJI7

Accession Number

Q9JJI7

Expression System

E.coli

Tag

N-His

Sequence

Lys 591-Val 855

Field of Research

Signal Transduction; Cancer; Cell Biology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

29.0 kDa

Observed Molecular Weight

34 kDa

Species

Rat