Recombinant Human FGFBP2 Protein (Sumo Tag)

Specifications

Catalog number

PDEH101150-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

FGFBP2 (Fibroblast Growth Factor Binding Protein 2), a secreted chaperone, regulates fibroblast growth factors (FGFs) —key signaling molecules critical for tissue repair, angiogenesis, and cell proliferation—by binding specific ligands (e.g., FGF-1, FGF-2) through a conserved domain to enhance their release from extracellular storage or receptor interactions. Primarily expressed in regenerative or metabolically active tissues (e.g., liver, kidney, epithelia), FGFBP2 is tightly controlled under normal conditions but often overexpressed in cancers, where it amplifies FGF-driven tumor progression by promoting angiogenesis, survival, and metastasis, while also being implicated in metabolic disorders and inflammation through potential links to insulin resistance and fibrosis. Though functionally overlapping with its paralog FGFBP1, FGFBP2 exhibits distinct tissue-specific expression and ligand preferences, with ongoing research focused on elucidating its mechanistic roles in FGF signaling and exploring its therapeutic or biomarker potential in cancer and FGF-associated diseases.

Abbreviation

FGFBP2

Synonyms

Fibroblast growth factor-binding protein 2

UniProt

Q9BYJ0

Accession Number

Q9BYJ0

Expression System

E.coli

Tag

N-Sumo

Sequence

Gln20-Gly223

Field of Research

Developmental Biology; Signal Transduction

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method

Purity

> 85% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

37.33 kDa

Observed Molecular Weight

40 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human