RUVB2 Recombinant Mouse Monoclonal Antibody [A1E12-R]

Catalog number HA601239

Price for HA601239

Size / count 100 µL

About this product

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes.

Specifications

Catalog number: HA601239
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: 48 kDa TATA box-binding protein-interacting protein antibody 48 kDa TBP-interacting protein antibody 48-kDa TATA box-binding protein-interacting protein antibody 48-kDa TBP-interacting protein antibody 51 kDa erythrocyte cytosolic protein antibody CGI-46 antibody EC=3.6.1.- antibody ECP-51 antibody ECP51 antibody Erythrocyte cytosolic protein, 51-KD antibody INO80 complex subunit J antibody INO80J antibody MGC144733 antibody MGC144734 antibody MGC52995 antibody mp47 antibody p47 antibody p47 protein antibody Repressing pontin 52 antibody Reptin 52 antibody REPTIN antibody RuvB (E coli homolog)-like 2 antibody RUVB, E. coli, homolog-like 2 antibody RuvB-like 2 (E. coli) antibody RuvB-like 2 antibody RuvB-like protein 2 antibody RUVB2 antibody RUVB2_HUMAN antibody RUVBL2 antibody RVB2 antibody TAP54-beta antibody TATA box-binding protein-interacting protein, 48-KD antibody TBP-interacting protein, 48-KD antibody TIH2 antibody TIP48 antibody TIP49b antibody TIP60-associated protein 54-beta antibody wu:fi25f01 antibody zreptin antibody
Abbreviation: RUVBL2
Swiss Prot: Q9Y230 Human, Q9WTM5 Mouse,
Cellular Locus: Nucleus matrix, nucleoplasm, cytoplasm, membrane.
Host: Mouse
Species Reactivity: Human, Mouse, Rat, Monkey
Immunogen: Recombinant protein within Human RUVB2 aa 130-321 / 463.
Isotype: IgG1
Clone: A1E12-R
Conjugation: Non-conjugated
Type: Recombinant Mouse monoclonal Antibody
Applications: WB, IF-Cell, IHC-P
Positive Control: HeLa cell lysate, Daudi cell lysate, HepG2 cell lysate, SK-Br-3 cell lysate, 293T cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, C6 cell lysate, PC-12 cell lysate, COS-1 cell lysate, mouse testis tissue lysate, rat testis tissue lysate, mouse thymus tissue lysate, rat thymus tissue lysate, HeLa, RAW264.7, human testis tissue, mouse testis tissue, rat testis tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:2,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 51 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for RUVB2 Recombinant Mouse Monoclonal Antibody [A1E12-R]?

The catalog number for RUVB2 Recombinant Mouse Monoclonal Antibody [A1E12-R] is HA601239.

What sizes are available for RUVB2 Recombinant Mouse Monoclonal Antibody [A1E12-R]?

RUVB2 Recombinant Mouse Monoclonal Antibody [A1E12-R] is available in the following size(s): 100 µL.

Is RUVB2 Recombinant Mouse Monoclonal Antibody [A1E12-R] in stock?

RUVB2 Recombinant Mouse Monoclonal Antibody [A1E12-R] is currently made to order / not held in immediate stock. Contact us for lead time.

What is RUVB2 Recombinant Mouse Monoclonal Antibody [A1E12-R] used for?

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.