MCT1 Recombinant Rabbit Monoclonal Antibody [JE41-72]

Catalog number HA722556

Price for HA722556

Size / count 100 µL

About this product

Monocarboxylate transporter 1 is a ubiquitous protein that in humans is encoded by the SLC16A1 gene (also known as MCT1). It is a proton coupled monocarboxylate transporter. Detailed kinetic analysis of monocarboxylate transport in erythrocytes revealed that MCT1 operates through an ordered mechanism. MCT1 has a substrate binding site open to the extracellular matrix which binds a proton first followed by the lactate anion. The protein then undergoes a conformational change to a new ‘closed’’ conformation that exposes both the proton and lactate to the opposite surface of the membrane where they are released, lactate first and then the proton. For net transport of lactic acid, the rate-limiting step is the return of MCT1 without bound substrate to the open conformation. For this reason, exchange of one monocarboxylate inside the cell with another outside is considerably faster than net transport of a monocarboxylate across the membrane. MCT1 can be upregulated by PPAR-α, Nrf2, and AMPK.

Specifications

Catalog number: HA722556
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: FLJ36745 antibody HHF7 antibody MCT 1 antibody MCT antibody MGC44475 antibody Monocarboxylate transporter 1 antibody Monocarboxylate transporter antibody Monocarboxylate transporter isoform 1 antibody Monocarboxylic acid transporter 1 antibody MOT1_HUMAN antibody Slc16a1 antibody SLC16A1 protein antibody Solute carrier family 16 (monocarboxylic acid transporters) member 1 antibody Solute carrier family 16 member 1 (monocarboxylic acid transporter 1) antibody Solute carrier family 16 member 1 antibody
Abbreviation: SLC16A1, MCT1
Swiss Prot: P53985 Human
Cellular Locus: Cell membrane, Basolateral cell membrane, Apical cell membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within
Isotype: IgG
Clone: JE41-72
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: HeLa cell lysate, HepG2 cell lysate, Jurkat cell lysate, 293T cell lysate, BxPC-3 cell lysate, AGS cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 54 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for MCT1 Recombinant Rabbit Monoclonal Antibody [JE41-72]?

The catalog number for MCT1 Recombinant Rabbit Monoclonal Antibody [JE41-72] is HA722556.

What sizes are available for MCT1 Recombinant Rabbit Monoclonal Antibody [JE41-72]?

MCT1 Recombinant Rabbit Monoclonal Antibody [JE41-72] is available in the following size(s): 100 µL.

Is MCT1 Recombinant Rabbit Monoclonal Antibody [JE41-72] in stock?

MCT1 Recombinant Rabbit Monoclonal Antibody [JE41-72] is currently made to order / not held in immediate stock. Contact us for lead time.

What is MCT1 Recombinant Rabbit Monoclonal Antibody [JE41-72] used for?

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.