KDM4A Recombinant Rabbit Monoclonal Antibody [JE36-54]

About this product

Lysine-specific demethylase 4A is an enzyme that in humans is encoded by the KDM4A gene. This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily. It functions as a trimethylation-specific demethylase, converting specific trimethylated histone on histone H3 lysine 9 and 36 residues to the dimethylated form and lysine 9 dimethylated residues to monomethyl, and as a transcriptional repressor. Alterations in this gene have been found associated with chromosomal instability that leads to cancer. In humans, the role of Kdm4a as an oncogene, or cancer associated gene, is well established. It is implicated in prostate tumors, where it is overexpressed, and stimulates cell proliferation in colon cancer cells, where it promotes formation of the tumor itself. In lung cancer cell lines, where Kdm4a is also overexpressed, it coordinates with other oncogenes (like Ras) to transform normal cells into cancerous cells by inhibiting tumor suppressor pathways such as p53. Suppression of Kdm4a in breast cancer cell lines has shown to reduce cancer cell proliferation through cell cycle arrest, and decrease tumor migration and invasion.

Specifications

Catalog number

HA721336

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

JHDM3A antibody JmjC domain containing histone demethylation protein 3A antibody JmjC domain-containing histone demethylation protein 3A antibody JMJD2 antibody JMJD2A antibody jumonji C domain containing histone demethylase 3A antibody Jumonji domain containing 2 antibody Jumonji domain containing 2A antibody Jumonji domain containing protein 2A antibody Jumonji domain-containing protein 2A antibody KDM4A antibody KDM4A_HUMAN antibody KIAA0677 antibody Lysine (K) specific demethylase 4A antibody Lysine-specific demethylase 4A antibody TDRD14A antibody Tudor domain containing 14A antibody

Abbreviation

KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677

Swiss Prot

O75164 Human, Q8BW72 Mouse,

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human KDM4A aa 551-650 / 1,064.

Isotype

IgG

Clone

JE36-54

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

MG-63 cell lysate, mouse cerebellum tissue lysate, mouse brain tissue lysate, rat brain tissue lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 121 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes