AF/LE Purified Anti-Human IL-10 Antibody[JES3-9D7]

Specifications

Catalog number

E-AB-F11980-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, prolifeRation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Abbreviation

IL-10

Gene ID

3586

UniProt

P22301

Host

Rat

Reactivity

Human

Immunogen

Recombinant Human IL-10 protein

Target

Interleukin; RP11-262N; CSIF; GVHDS; IL-10; IL10A; TGIF; IL10; Cytokine synthesis inhibitory factor; Interleukin-10; MGC126450; MGC126451; RP11-262N9.1

Clonality

Monoclonal

Clone

JES3-9D7

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Immunology; Cancer

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Isotype

Rat IgG1, κ