Purified Anti-Human IL-21 Antibody[3A3-N2]

Specifications

Catalog number

E-AB-F1202A-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-21 (IL-21) is the most recently described cytokine belonging to the common cytokine receptor gamma-chain family. Like other common gamma chain family members, IL-21 is a four alpha-helix bundle type I cytokine. It signals through a receptor complex consisting of IL-21 R and common gamma-chain/IL-2 R gamma. IL-21 is produced primarily by CD4+ T cells and natural killer T (NKT) cells and has a broad range of effects on a number of different cell types. IL-21 signaling in CD4+ T cells is required for both Th17 differentiation and the geneRation of T follicular helper (Tfh) cells, which support B cell differentiation and antibody production in germinal centers. IL-21 also directly regulates B cell prolifeRation and apoptosis in a context-dependent manner and can promote immunoglobulin production and isotype class switching. In addition, IL-21 signaling enhances the cytotoxicity of CD8+ T cells, natural killer cells, and NKT cells.

Abbreviation

IL-21

UniProt

Q9HBE4

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human IL-21 protein

Target

CVID; Interleukin; IL21; CVID11; IL-21; Za11; Interleukin-21

Clonality

Monoclonal

Clone

3A3-N2

Conjugation

Unconjugated

Applications

FCM

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

PBS, pH 7.2. Contains 0.05% proclin 300.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Isotype

Mouse IgG1, κ