Purified Anti-Mouse CD107a Antibody[1D4B]

Specifications

Catalog number

E-AB-F1254A-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.

Abbreviation

CD107a

Gene ID

16783

UniProt

P11438

Host

Rat

Reactivity

Mouse

Immunogen

Recombinant Mouse CD107a protein

Target

LGP; lysosomal membrane glycoprotein; Lysosome-associated membrane glycoprotein;120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; CD107a; LGP-120; LGP-A; lysosomal membrane glycoprotein 1; Lysosomal membrane glycoprotein A; Lysosome-associated membrane glycoprotein 1; lysosome-associated membrane protein 1; P2B; Lamp-1; Lamp1; LGP-120

Clonality

Monoclonal

Clone

1D4B

Conjugation

Unconjugated

Applications

FCM

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

PBS, pH 7.2. Contains 0.05% proclin 300.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Isotype

Rat IgG2a, κ