CD10 Monoclonal Antibody

Specifications

Catalog number

AN200185P

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) . This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Abbreviation

MME

UniProt

P08473

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human CD10 Protein

Target

SCA; Neutral endopeptidase 24.; CALLA; CD10; CMT2T; NEP; SCA43; SFE; MME; Atriopeptidase; Common acute lymphocytic leukemia antigen; Enkephalinase; Neprilysin; Neutral endopeptidase; Neutral endopeptidase 24.11; Skin fibroblast elastase; EPN; NEP; gp100; CD10 antigen; CD10) ; DKFZp686O16152; EC 3.4.24.11; enkephalinase) ; Membrane metallo endopeptidase; Membrane metallo endopeptidase (neutral endopeptidase; Membrane metallo endopeptidase variant 1; Membrane metallo endopeptidase variant 2; Membrane metalloendopeptidase; Membrane metalloendopeptidase neutral endopeptidase enkephalinase; Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10; Membrane metalloendopeptidase variant 1; Membrane metalloendopeptidase variant 2; membrane-associated; MGC126681; MGC126707; neprilysin-390; neprilysin-411

Clonality

Monoclonal

Clone

6A10

Conjugation

Unconjugated

Applications

WB; IHC-P; IP

Field of Research

Immunology; Stem Cells; Cancer

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IHC-P 1:20-1:100; IP 1-5 μL/mg of lysate

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

85 kDa

Observed Molecular Weight

95 kDa

Isotype

IgG1