P4HB/ERBA2L Monoclonal Antibody

Specifications

Catalog number

AN200187P-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.

Abbreviation

P4HB

UniProt

P07237

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human P4HB protein

Target

PDIA; CLCRP; P4HB; CLCRP1; DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB; Cellular thyroid hormone-binding protein; p55; Prolyl 4-hydroxylase subunit beta; Protein Disulfide-Isomerase

Clonality

Monoclonal

Clone

10F7

Conjugation

Unconjugated

Applications

IHC-P

Field of Research

Signal Transduction; Cancer; Metabolism; Tags & Cell Markers

Purification

Protein A

Concentration

1 mg/mL

Dilution

IHC-P 1:20-1:80

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Isotype

IgG1