CD113/Nectin-3 Monoclonal Antibody

Catalog number AN200188P

Price for AN200188P

Size / count 100 µL

Specifications

Catalog number: AN200188P
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest) . It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in the reduction of cell movement and proliferation.
Abbreviation: NECTIN3
UniProt: Q9NQS3
Host: Mouse
Reactivity: Human
Immunogen: Recombinant Human CD113/Nectin-3 protein
Target: PRR; CDw; PPR; PVRL; Poliovirus receptor-like; Poliovirus receptor related; Poliovirus receptor related protein; PVRR; DKFZP566B; CD113; CDw113; DKFZP566B0846; FLJ90624; Nectin-3; Poliovirus receptor related 3; Poliovirus receptor related protein 3; Poliovirus receptor-like 3; Poliovirus Receptor-Related Protein 3; PPR3; PVRR3; PRR3; PVRL3; NECTIN3; Nectin-3; PRR3; CDw113
Clonality: Monoclonal
Clone: 10F10
Conjugation: Unconjugated
Applications: IHC-P
Field of Research: Immunology; Microbiology
Purification: Protein A
Concentration: 1 mg/mL
Dilution: IHC-P 1:50-1:200
Buffer: 0.2 μm filtered solution in PBS
Shipping Conditions: Ice bag
Storage Conditions: This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Isotype: IgG1

Frequently Asked Questions

What is the catalog number for CD113/Nectin-3 Monoclonal Antibody?

The catalog number for CD113/Nectin-3 Monoclonal Antibody is AN200188P.

What sizes are available for CD113/Nectin-3 Monoclonal Antibody?

CD113/Nectin-3 Monoclonal Antibody is available in the following size(s): 100 µL.

Is CD113/Nectin-3 Monoclonal Antibody in stock?

CD113/Nectin-3 Monoclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CD113/Nectin-3 Monoclonal Antibody?

CD113/Nectin-3 Monoclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for CD113/Nectin-3 Monoclonal Antibody?

Estimated delivery time for CD113/Nectin-3 Monoclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CD113/Nectin-3 Monoclonal Antibody?

The safety data sheet for CD113/Nectin-3 Monoclonal Antibody is available here: https://789.bio/eb/a7KP21g2.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.