Recombinant Vimentin Monoclonal Antibody

Specifications

Catalog number

AN300290P

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. Therefore, in general, it is accepted that vimentin is the cytoskeletal component responsible for maintaining cell integrity. Vimentin is also responsible for stabilizing cytoskeletal interactions. It is found that vimentin control the transport of low-density lipoprotein. It has been used as a sarcoma tumor marker to identify mesenchyme.

Abbreviation

VIM

UniProt

P08670

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human Vimentin Protein

Target

HEL; Epididymis luminal protein; CTRCT; CTRCT30; HEL113; Vimentin; VIM; Epididymis luminal protein 113; VIME; FLJ36605; epididymis secretory sperm binding protein; CTRCT30; HEL113; vimentin; CTRCT30; Epididymis luminal protein 113; FLJ36605; HEL113; VIM; VIME; Vimentin

Clonality

Monoclonal

Clone

2B8

Conjugation

Unconjugated

Applications

IHC-P

Field of Research

Neuroscience; Signal Transduction; Stem Cells; Cancer; Developmental Biology

Purification

Protein A

Concentration

1 mg/mL

Dilution

IHC-P 1:1000-1:5000

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Isotype

IgG