Recombinant JNK2/MAPK9 Monoclonal Antibody

Specifications

Catalog number

AN300348P

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Abbreviation

MAPK9

UniProt

P45984

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human JNK2/MAPK9 protein

Target

MAPK; PRKM; JNK; MAPK9; JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; PRKM9; SAPK; SAPK1a; p54a; p54aSAPK; c Jun kinase 2; C Jun N terminal kinase 2; c-Jun N-terminal kinase 2; JNK 55; JNK2 alpha; JNK2 beta; Jun kinase; MAP kinase 9; MAPK 9; Mitogen activated protein kinase 9; mitogen-activated; Mitogen-activated protein kinase 9; MK09; Protein kinase; SAPK alpha; Stress activated protein kinase 1a; Stress-activated protein kinase JNK2

Clonality

Monoclonal

Clone

6A9

Conjugation

Unconjugated

Applications

WB; IHC-P; ICC/IF; IP

Field of Research

Signal Transduction; Cell Biology; Cancer; Immunology; Metabolism; Epigenetics and Nuclear Signaling

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000; IHC-P 1:500-1:2500; ICC/IF 1:100-1:500; IP 1-2 μL/mg of lysate

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

48 kDa

Observed Molecular Weight

54 kDa

Isotype

IgG