Recombinant ADSL/Adenylosuccinate Lyase Monoclonal Antibody

Specifications

Catalog number

AN300398P

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Adenylosuccinate lyase, also known as adenylosuccinase, ADSL or ASL, is an enzyme implicated in the reaction of adenylosuccinat converting to AMP and fumarate as part of the purine nucleotide cycle. The two substates of adenylosuccinate lyase (ADSL) are dephosphorylated derivatives of SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP), which catalyzes an important reaction in the de novo pathway of purine biosynthesis. ADSL catalyzes two distinct reactions in the synthesis of purine nucleotides, both of which involve the _-elimination of fumarate to produce either aminoimidazole carboxamide ribotide from SAICAR or AMP from S-AMP. The Adenylosuccinate lyase deficiency is a rare autosomal recessive metabolic disorder characterized by the present of SAICA riboside and succinyladenosine (S-Ado) . ADSL defect in different patients is often caused by different mutations to the enzyme.

Abbreviation

ADSL

UniProt

P30566

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human ADSL/Adenylosuccinate Lyase protein

Target

ASASE; ASL; AMPS; ADSL

Clonality

Monoclonal

Clone

9D3

Conjugation

Unconjugated

Applications

WB; ICC/IF; IP

Field of Research

Signal Transduction; Metabolism

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; ICC/IF 1:20-1:100; IP 1-4 μL/mg of lysate

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

55 kDa

Observed Molecular Weight

55 kDa

Isotype

IgG