Recombinant ARG1/Arginase 1 Monoclonal Antibody

Specifications

Catalog number

AN300403P

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN) . Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion.

Abbreviation

ARG1

UniProt

P05089

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human ARG1/Arginase 1 protein

Target

ARGI; ARG; ARG1; arginase-1; A I; Al; ARG 1; ARGI1; Arginase; Arginase 1; Arginase I; Arginase liver; Arginase type I; Arginase1; liver; Liver Arginase; Liver type arginase; Liver-type arginase; Type I arginase; A I; Al; ARG 1; arg1; ARGI1; Arginase 1; Arginase liver; Arginase type I; Arginase; liver; Arginase-1; Arginase1; Liver type arginase; Liver-type arginase; Type I arginase; Arginase

Clonality

Monoclonal

Clone

9D10

Conjugation

Unconjugated

Applications

WB; IHC-P; FCM; ICC/IF

Field of Research

Signal Transduction; Metabolism

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000; IHC-P 1:500-1:2500; ICC/IF 1:20-1:100; FCM 1:100-1:500

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

35 kDa

Observed Molecular Weight

40 kDa

Isotype

IgG