Recombinant RRM2B/P53R2 Monoclonal Antibody

Specifications

Catalog number

AN300433P

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.

Abbreviation

RRM2B

UniProt

Q7LG56

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human RRM2B/P53R2 protein

Target

P53R; RRM2B; MTDPS8A; MTDPS8B; P53R2

Clonality

Monoclonal

Clone

4B11

Conjugation

Unconjugated

Applications

IHC-P; ICC/IF

Field of Research

Epigenetics and Nuclear Signaling; Cancer; Metabolism

Purification

Protein A

Concentration

1 mg/mL

Dilution

IHC-P 1:100-1:500; ICC/IF 1:20-1:100

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Isotype

IgG