Recombinant MSR1/CD204 Monoclonal Antibody

Specifications

Catalog number

AN300480P-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD24, MSR1, and SCARA1, is a single-pass type II membrane protein that contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1) . MSR1/SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low-density lipoproteins (LDL) . MSR1/SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.

Abbreviation

MSR1

UniProt

P30204

Host

Rabbit

Reactivity

Mouse

Immunogen

Recombinant Mouse MSR1/CD204 protein

Target

MSR; Scvr; Msr1

Clonality

Monoclonal

Clone

5C3

Conjugation

Unconjugated

Applications

IHC-P; FCM; ICC/IF

Purification

Protein A

Concentration

1 mg/mL

Dilution

IHC-P 1:50-1:200; ICC/IF 1:50-1:1000; FCM 1:25-1:100

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Isotype

IgG