Recombinant MAP2 Monoclonal Antibody

Specifications

Catalog number

AN300528P

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

METAP2 (Methionine aminopeptidase 2), also known as MAP2 is a protein that belongs to the peptidase M24A family. MAP2 binds 2 cobalt or manganese ions and contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. It is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation. The catalytic activity of human MAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. MAP2 protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. It also plays a critical role in the regulation of protein synthesis.

Abbreviation

METAP2

UniProt

O08663

Host

Rabbit

Reactivity

Mouse

Immunogen

Recombinant Mouse MAP2 protein

Target

Amp; METAP; P67eif;4930584B20Rik; A930035J23Rik; AI047573; AL024412; Amp2; AU014659; p67; Mnpep; P67eif2; Metap2

Clonality

Monoclonal

Clone

7A2

Conjugation

Unconjugated

Applications

IHC-P

Purification

Protein A

Concentration

1 mg/mL

Dilution

IHC-P 1:500-1:2000

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Isotype

IgG