Recombinant Cyclin D1 Monoclonal Antibody

Specifications

Catalog number

AN301028L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Abbreviation

Cyclin D1

UniProt

P24385

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Human Cyclin D1 protein

Target

Cyl; PRAD; U21B; CCND; B cell leukemia; G1/S specific cyclin D; Cyclin D; BCL; BCL1; D11S287E; PRAD1; U21B31; CCND1; Cyclin D1; B cell leukemia 1; BCL 1; Cd1; Cyl 1; G1/S specific cyclin D1; BCL1; D11S287E; PRAD1; U21B31; CCND1; Cyclin D1; cyclin D1

Clonality

Monoclonal, Recombinant

Clone

5A3

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cell Biology; Epigenetics and Nuclear Signaling; Cancer

Purification

Protein A

Concentration

0.2 mg/mL

Dilution

IHC 1:200-1:1000; WB 1:1000-1:5000

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

34 kDa

Observed Molecular Weight

36 kDa

Isotype

IgG, κ