Recombinant Mucin 5AC Monoclonal Antibody

Specifications

Catalog number

AN301037L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding., Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particules that are subsequently removed by the mucocilary system., PTM:C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis., PTM:Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide., similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain., similarity:Contains 2 VWFC domains., similarity:Contains 4 VWFD domains., subunit:Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) ., tissue specificity:Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.

Abbreviation

Mucin 5AC

UniProt

P98088

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Human Mucin 5AC protein

Target

Gastric mucin|mucin; MUC; MUC5AC; MUC5; TBM; leB; mucin; mucin-5AC; MUC5A; Apomucin; Gastric mucin; gastric mucin|mucin 5; Major airway glycoprotein; MUC 5; Mucin 5 Subtypes A And C; Mucin 5AC; Mucin-5 subtype AC; subtypes A and C; tracheobronchial; tracheobronchial/gastric|mucin 5AC|tracheobronchial mucin; MUC-5AC; Mucin 5 Subtype AC; Tracheobronchial mucin; Apomucin Major Airway Glycoprotein; Lewis B blood group antigen; Mucin 5; Mucin 5 subtype AC tracheobronchial; Mucin 5 subtypes A and C tracheobronchial/gastric; Mucin 5AC oligomeric mucus/gel forming; oligomeric mucus/gel forming pseudogene; Tracheobronchial Mucin (TBM) ; tracheobronchial/gastric; MUC5AC

Clonality

Monoclonal, Recombinant

Clone

6C4

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Signal Transduction; Cancer

Purification

Protein A

Concentration

0.2 mg/mL

Dilution

IHC 1:200-1:1000; WB 1:1000-1:5000

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

586 kDa

Observed Molecular Weight

586 kDa

Isotype

IgG, κ