Recombinant PD1 Monoclonal Antibody

Catalog number AN301420L-01

Choose a variant (2 options)

Selecting a variant updates its price, size and availability.

Price for AN301420L-01

Size / count 50 µL

Specifications

Catalog number: AN301420L-01
Size / count: 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: The programmed cell death 1 protein (PD1) is an inhibitory receptor expressed on antigen activated T-cells that plays a critical role in the induction and maintenance of immune tolerance to self-antigens. Upon binding to its ligands CD274/PDCD1L1 (PD-L1) and CD273/PDCD1LG2 (PD-L2), PD1 is phosphorylated within its immunoreceptor tyrosine-based switch motif (ITSM), which facilitates the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2. PTPN11/SHP-2 then dephosphorylates key T-cell receptor (TCR) proximal signaling molecules, including ZAP70, PRKCQ/PKC theta and CD247/CD3 zeta, leading to the direct inhibition of T-cell activation. The PD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and evade destruction by the immune system, thereby facilitating tumor survival.
Abbreviation: PD1
UniProt: Q15116
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide derived from the human PD1 protein
Target: SLEB; hSLE; Programmed Death; programmed cell death; Programmed cell death protein; Systemic lupus erythematosus susceptibility; hPD; PDCD1; CD279; PD-1; PD1; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death 1; PD 1; CD279 antigen; hPD 1; hPD l; PDCD 1; Programmed cell death 1 protein; Programmed Death-1; Protein PD 1; Protein PD-1; Systemic lupus erythematosus susceptibility 2; Programmed cell death protein 1; CD279; CD279 antigen; hPD 1; hPD l; hPD-1; hSLE1; PD 1; PD-1; PD1; PDCD 1; PDCD1; PDCD1; Programmed cell death 1; Programmed cell death 1 protein; Programmed cell death protein 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2
Clonality: Monoclonal, Recombinant
Clone: A115
Conjugation: Unconjugated
Applications: IHC; IF
Field of Research: Cell Biology; Immunology; Cancer
Purification: Protein A purified
Concentration: 1 mg/mL
Dilution: IHC 1:200-1:1000; IF 1:50
Buffer: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions: Ice bag
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype: IgG, κ

Frequently Asked Questions

What is the catalog number for Recombinant PD1 Monoclonal Antibody?

The catalog number for Recombinant PD1 Monoclonal Antibody is AN301420L.

What sizes are available for Recombinant PD1 Monoclonal Antibody?

Recombinant PD1 Monoclonal Antibody is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does Recombinant PD1 Monoclonal Antibody come in?

Recombinant PD1 Monoclonal Antibody is available in 2 different pack sizes.

Is Recombinant PD1 Monoclonal Antibody in stock?

Recombinant PD1 Monoclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant PD1 Monoclonal Antibody?

Recombinant PD1 Monoclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for Recombinant PD1 Monoclonal Antibody?

Estimated delivery time for Recombinant PD1 Monoclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant PD1 Monoclonal Antibody?

The safety data sheet for Recombinant PD1 Monoclonal Antibody is available here: https://789.bio/eb/C56sTqVJ.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.