Recombinant ABCE1 Monoclonal Antibody

Specifications

Catalog number

AN301424L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. Together with PELO and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and HBS1L, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. Plays a role in the regulation of mRNA turnover. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway.

Abbreviation

ABCE1

UniProt

P61221

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Recombinant human ABCE1 fragment

Target

ABC; ABCE; RNASEL; OK/SW-cl; ABCE1; ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI; RNS4I; OK/SW-cl.40;2' 5' oligoadenylate binding protein;2'5' oligoadenylate binding protein;2''-5''-oligoadenylate-binding protein; ABC 38; ABCE 1; ATP binding cassette sub family E (OABP) member 1; ATP binding cassette sub family E member 1; ATP-binding cassette sub-family E member 1; HuHP 68; HuHP68; Ribonuclease 4 inhibitor; Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) inhibitor; Ribonuclease L (2'5' oligoisoadenylate synthetase dependent) inhibitor; Ribonuclease L inhibitor; RNase L inhibitor; RNS 4I

Clonality

Monoclonal, Recombinant

Clone

A119

Conjugation

Unconjugated

Applications

WB; IF

Field of Research

Signal Transduction; Immunology

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000; IF 1:50

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

34 kDa

Observed Molecular Weight

45 kDa

Isotype

IgG, κ