Recombinant FGFR2 Monoclonal Antibody

Specifications

Catalog number

AN301522L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation.

Abbreviation

FGFR2

UniProt

P21802

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Recombinant human FGFR2 fragment

Target

CFD; BFR; ECT; CEK; FGFR; BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25; FGFR2; KSAM; BEK; K-SAM

Clonality

Monoclonal, Recombinant

Clone

A221

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cardiovascular; Signal Transduction; Neuroscience; Stem Cells; Cancer; Developmental Biology

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

IHC 1:50-1:100

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG, κ