Recombinant ARPC5/p16 ARC Monoclonal Antibody

Specifications

Catalog number

AN301616L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) .

Abbreviation

ARPC5/p16 ARC

UniProt

O15511

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Recombinant human ARPC5/p16 ARC fragment

Target

ARC; ARPC; dJ127C; ARPC5; ARC16; dJ127C7.3; p16-Arc

Clonality

Monoclonal, Recombinant

Clone

A319

Conjugation

Unconjugated

Applications

WB; IHC; IF; FCM

Field of Research

Signal Transduction

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:100; IF 1:50; FCM 1:50

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

16 kDa

Observed Molecular Weight

16 kDa

Isotype

IgG, κ