Recombinant PI3 Kinase p110 alpha Monoclonal Antibody

Specifications

Catalog number

AN301630L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns (4,5) P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) . PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.

Abbreviation

PI3 Kinase p110 alpha

UniProt

P42336

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Recombinant human PI3 Kinase p110 alpha fragment

Target

CWS; PIK3CA; CLOVE; CWS5; MCAP; MCM; MCMTC; PI3K; PI3K-alpha;5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha;5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha;5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha (PtdIns-3-kinase subunit p110-alpha;5-bisphosphate 3-kinase catalytic subunit alpha isoform; caPI3K; MGC142161; MGC142163; p110 alpha; p110alpha; Phosphatidylinositol 3 kinase catalytic 110 KD alpha; Phosphatidylinositol 3 kinase catalytic alpha polypeptide; Phosphatidylinositol 4; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform; Phosphatidylinositol-4; Phosphoinositide 3 kinase catalytic alpha polypeptide; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; PI3 kinase p110 subunit alpha; PI3Kalpha; PI3KC A; PI3-kinase subunit alpha; PIK3C A; PK3CA; PtdIns 3 kinase p110; PtdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA

Clonality

Monoclonal, Recombinant

Clone

A333

Conjugation

Unconjugated

Applications

WB; IHC; IF

Field of Research

Signal Transduction; Cancer; Immunology

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:50

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

110 kDa

Observed Molecular Weight

120 kDa

Isotype

IgG, κ