Recombinant SATB1 Monoclonal Antibody

Specifications

Catalog number

AN301653L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity) . Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.

Abbreviation

SATB1

UniProt

Q01826

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Recombinant human SATB1 fragment

Target

SATB; SATB1

Clonality

Monoclonal, Recombinant

Clone

A356

Conjugation

Unconjugated

Applications

IHC; IF

Field of Research

Epigenetics and Nuclear Signaling

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

IHC 1:200-1:1000; IF 1:50

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG, κ