Recombinant GABA A Receptor alpha 1 Monoclonal Antibody

Specifications

Catalog number

AN301811L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

GABA A Receptor alpha 1 is a subunit of the GABA A receptor protein. GABA A receptor consists of different combinations of five protein subunits, each produced from a different gene. These subunits form a hole (pore) in the cell membrane through which negatively charged chlorine atoms (chloride ions) can flow. A chemical that transmits signals in the brain (a neurotransmitter) called gamma-amino butyric acid (GABA) attaches to GABA A receptors. Once GABA attaches, the pore formed by the subunits opens, and chloride ions flow across the cell membrane. After infancy, chloride ions flow into the cell through the open pore, which creates an environment in the cell that blocks (inhibits) signaling between neurons. The primary role of GABA in children and adults is to prevent the brain from being overloaded with too many signals. In contrast, in newborns and infants, chloride ions flow out of the cell when the pore is opened, creating an environment that allows signaling between neurons.

Abbreviation

GABA A Receptor alpha 1

UniProt

P62812

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Recombinant human GABA A Receptor alpha 1 fragment

Target

Gabra-1; Gabra1

Clonality

Monoclonal, Recombinant

Clone

A523

Conjugation

Unconjugated

Applications

WB; IHC

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:100

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

52 kDa

Observed Molecular Weight

52 kDa

Isotype

IgG, κ