Recombinant QKI Monoclonal Antibody

Specifications

Catalog number

AN301863L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

QKI is a member of the signal transduction and activator of RNA (STAR) protein family of RNA-binding proteins. Mutations in the mouse Qki locus results in impaired myelin formation resulting in tremors. QKI proteins exist as homodimers, and disruption of the dimerization process is lethal in mice. QKI exists in different isoforms that differ in their C-terminus, resulting in unique subcellular localizations. The nuclear isoform of QKI, QKI-5, is involved in regulation of alternative splicing of MAG mRNA, which encodes for a protein important for myelin sheath formation and maintenance. QKI has also been implicated in schizophrenia and oligodendrocyte differentiation. QKI can function as a tumor suppressor, as it is regulated by p53 to stabilize miRNAs that regulate TGF-β signaling.

Abbreviation

QKI

UniProt

Q96PU8

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Recombinant human QKI fragment

Target

QKI; Hqk; QK; QK1; QK3; hqkI; HKQ

Clonality

Monoclonal, Recombinant

Clone

A575

Conjugation

Unconjugated

Applications

WB; IF

Field of Research

Neuroscience; Epigenetics and Nuclear Signaling

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:500-1:3000; IF 1:50

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

38 kDa

Observed Molecular Weight

38 kDa

Isotype

IgG, κ