Recombinant TNF receptor II Monoclonal Antibody

Specifications

Catalog number

AN301888L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

TNF receptor II (TNF-R2) is one of the receptors of TNF-α. The two receptors for TNF-α, TNF-R1 (55 kDa) and TNF-R2 (75 kDa), can mediate distinct cellular responses. In most cases, cytotoxicity elicited by TNF has been reported to act through TNF-R1. In contrast, TNF-R2 appears to be important in T cell signaling and responses to infection. TNF-R2 binds to distinct members of the TRAF family, leading to the activation of NF-κB. Soluble forms of both receptors have also been characterized which can bind TNF-α and may play an important role in immune disorders.

Abbreviation

TNF receptor II

UniProt

P20333

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Recombinant human TNF receptor II fragment

Target

Soluble TNFR1B variant; Tumor necrosis factor receptor; tumor necrosis factor binding protein; CD120b; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80; p75; p75TNFR; TNF Receptor II; TNFRSF1B; p80 TNF-alpha receptor; Tumor Necrosis Factor Receptor II; Etanercept; P75tbpii; TNF-R2; TNFR2TNFR1B; TNFRII; TNF-RII; TNFR-II; CD120b antigen; p75 TNF receptor; soluble TNFR1B variant 1; TNF RII; TNFBRp80 TNF-alpha receptor; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily; member 1B; Tumor necrosis factor receptor type II; p80; Tumor Necrosis Factor Receptor II

Clonality

Monoclonal, Recombinant

Clone

A604

Conjugation

Unconjugated

Applications

WB; IHC; IF

Field of Research

Cell Biology; Immunology; Signal Transduction; Cancer; Cardiovascular; Neuroscience

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000; IHC 1:50-1:100; IF 1:50

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

48 kDa

Observed Molecular Weight

63 kDa

Isotype

IgG, κ