Recombinant TFF1/pS2 Monoclonal Antibody

Specifications

Catalog number

AN301892L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

TFF1/pS2 is a gastric peptide that is highly expressed by mucosal goblet cells of the stomach, where it is thought to play a role in maintaining the integrity of the epithelial layer of the mucosa through the regulation of cell-cell adhesion and cell migration. Research studies have shown that TFF1 functions as a tumor suppressor in the stomach as its expression is frequently lost in gastric carcinomas, largely due to promoter hypermethylation. Research studies have also demonstrated that TFF1 is a transcriptional target of estrogen receptor-α and that TFF1 expression in breast carcinoma may be used as a predictive biomarker for response to anti-estrogen therapy.

Abbreviation

TFF1/pS2

UniProt

P04155

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant human TFF1/pS2 fragment

Target

TFF; pNR; HPS; D21S; Protein Ps; Trefoil factor; TFF1; BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2; Breast cancer estrogen-inducible protein; Polypeptide P1.A; Protein Ps2; Trefoil factor 1

Clonality

Monoclonal, Recombinant

Clone

A608

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Signal Transduction

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:100

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

10 kDa

Observed Molecular Weight

13 kDa

Isotype

IgG, κ