Recombinant TGF beta 1 Monoclonal Antibody

Specifications

Catalog number

AN301902L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis. TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII), and type III (RIII) . Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases. The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain. Expression of the type III receptor can regulate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription.

Abbreviation

TGF beta 1

UniProt

P01137

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Recombinant human TGF beta 1 fragment

Target

DPD; Transforming growth factor beta; TGF-B; TGFB1; CED; DPD1; LAP; TGFB; TGFbeta; TGF-β; Cartilage-inducing factor; Differentiation inhibiting factor; IBDIMDE; TGF-B1; TGF-beta 1; TGF-beta-1; TGF-β1; Transforming growth factor beta-1 proprotein; Latency-associated peptide; Transforming growth factor beta-1; beta 1; Prepro transforming growth factor beta 1; TGF beta; TGF beta 1; TGF beta 1 protein; Tgfb-1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-5; transforming growth factor; Transforming Growth Factor b1; Transforming Growth Factor beta 1; Transforming growth factor beta 1a; Transforming Growth Factor-1

Clonality

Monoclonal, Recombinant

Clone

A618

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Signal Transduction; Stem Cells; Cancer; Metabolism; Cardiovascular; Cell Biology

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:1000; IHC 1:500-1:1000

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

44 kDa

Observed Molecular Weight

44, 10 kDa

Isotype

IgG, κ