Recombinant TMS1/ASC Monoclonal Antibody — image 1 of 3

Product details

Recombinant TMS1/ASC Monoclonal Antibody

Catalog number AN301903L-01

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Price for AN301903L-01

Size / count 50 µL

Specifications

Catalog number: AN301903L-01
Size / count: 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Target of methylation-induced silencing (TMS1) /Apoptosis-associated speck-like protein containing a CARD (ASC), also referred to as PYCARD and CARD5, is a 22-kDa pro-apoptotic protein containing an N-terminal pyrin domain (PYD) and a C-terminal caspase recruitment domain (CARD) . The ASC/TMS1 gene was originally found to be aberrantly methylated and silenced in breast cancer cells, and has since been found to be silenced in a number of other cancers, including ovarian cancer, glioblastoma, melanoma, gastric cancer, lung cancer, and prostate cancer. Expression of ASC/TMS1 can be induced by pro-apoptotic/inflammatory stimuli. During apoptosis ASC/TMS1 is re-distributed from the cytosol to the mitochondria and associates with mitochondrial Bax to trigger cytochrome c release and subsequent apoptosis. ASC/TMS1 has also been found to be a critical component of inflammatory signaling where it associates with and activates caspase-1 in response to pro-inflammatory signals.
Abbreviation: TMS1/ASC
UniProt: Q9ULZ3
Host: Rabbit
Reactivity: Human
Immunogen: Recombinant human TMS1/ASC fragment
Target: CARD; ASC / TMS; PYCARD; ASC; CARD5; TMS; TMS-1; TMS1; PYD and CARD domain containing; ASC / TMS1; Apoptosis associated speck like protein containing a CARD; Apoptosis-associated speck-like protein containing a CARD; CARD 5; Caspase recruitment domain containing protein 5; Caspase recruitment domain protein 5; Caspase recruitment domain-containing protein 5; hASC; MGC10332; PYD and CARD domain containing protein; PYD and CARD domain-containing protein; Target of methylation induced silencing 1; Target of methylation-induced silencing 1; TMS 1
Clonality: Monoclonal, Recombinant
Clone: A619
Conjugation: Unconjugated
Applications: WB; IHC; IF
Field of Research: Cell Biology; Cancer
Purification: Protein A purified
Concentration: 1 mg/mL
Dilution: WB 1:1000; IHC 1:100-1:500; IF 1:50
Buffer: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions: Ice bag
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 22, 15 kDa
Observed Molecular Weight: 22, 15 kDa
Isotype: IgG, κ

Frequently Asked Questions

What is the catalog number for Recombinant TMS1/ASC Monoclonal Antibody?

The catalog number for Recombinant TMS1/ASC Monoclonal Antibody is AN301903L.

What sizes are available for Recombinant TMS1/ASC Monoclonal Antibody?

Recombinant TMS1/ASC Monoclonal Antibody is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does Recombinant TMS1/ASC Monoclonal Antibody come in?

Recombinant TMS1/ASC Monoclonal Antibody is available in 2 different pack sizes.

Is Recombinant TMS1/ASC Monoclonal Antibody in stock?

Recombinant TMS1/ASC Monoclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant TMS1/ASC Monoclonal Antibody?

Recombinant TMS1/ASC Monoclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for Recombinant TMS1/ASC Monoclonal Antibody?

Estimated delivery time for Recombinant TMS1/ASC Monoclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant TMS1/ASC Monoclonal Antibody?

The safety data sheet for Recombinant TMS1/ASC Monoclonal Antibody is available here: https://789.bio/eb/5A86riVq.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.