Recombinant CPS1 Monoclonal Antibody — image 1 of 4

Product details

Recombinant CPS1 Monoclonal Antibody

Catalog number AN301906L-01

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Price for AN301906L-01

Size / count 50 µL

Specifications

Catalog number: AN301906L-01
Size / count: 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Carbamoyl phosphate synthetase 1 (CPS1), a rate-limiting enzyme in the urea cycle, catalyzes the conversion of ammonia and bicarbonate to carbamoyl phosphate in mitochondria. Non-small cell lung carcinoma (NSCLC) cells with oncogenic KRAS and loss of the tumor suppressor LKB1 express CPS1 and depend on this enzyme for growth. CPS1 maintains pyrimidine/purine balance in these cancer cells. Silencing CPS1 reduces the pyrimidine to purine ratio and stalls DNA synthesis, leading to DNA damage and cancer cell death. In addition, the tumor suppressor p53 represses the expression of urea cycle enzymes CPS1, OTC, and ARG1 and, therefore, causes the accumulation of ammonia, suppressing cancer growth. Furthermore, research studies suggest that hypermethylation-mediated downregulation of CPS1 expression may contribute to the progression of normal hepatocytes to hepatocellular carcinoma (HCC) .
Abbreviation: CPS1
UniProt: P31327
Host: Rabbit
Reactivity: Human; Rat; Mouse
Immunogen: Recombinant human CPS1 fragment
Target: CPS; carbamoyl-phosphate synthase; CPSASE; CPS1; CPSASE1; PHN; carbamoyl-phosphate synthase 1; carbamoyl-phosphate synthase 1; CPSASE1; PHN; Carbamoyl phosphate synthase; Carbamoyl phosphate synthase [ammonia]; Carbamoyl phosphate synthase [ammonia] mitochondrial; Carbamoyl phosphate synthetase 1; Carbamoyl phosphate synthetase 1 mitochondrial; Carbamoyl phosphate synthetase I; Carbamoylphosphate synthase; Carbamoyl-phosphate synthase [ammonia]; Carbamoylphosphate synthetase 1; Carbamoylphosphate synthetase I; Carbamoyl-phosphate synthetase I; CPS 1; CPSase 1; CPSase I; CPSM; mitochondrial; MS738
Clonality: Monoclonal, Recombinant
Clone: A622
Conjugation: Unconjugated
Applications: WB; IHC
Field of Research: Tags & Cell Markers; Signal Transduction; Metabolism
Purification: Protein A purified
Concentration: 1 mg/mL
Dilution: WB 1:1000-1:5000; IHC 1:50-1:100
Buffer: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions: Ice bag
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 165 kDa
Observed Molecular Weight: 165 kDa
Isotype: IgG, κ

Frequently Asked Questions

What is the catalog number for Recombinant CPS1 Monoclonal Antibody?

The catalog number for Recombinant CPS1 Monoclonal Antibody is AN301906L.

What sizes are available for Recombinant CPS1 Monoclonal Antibody?

Recombinant CPS1 Monoclonal Antibody is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does Recombinant CPS1 Monoclonal Antibody come in?

Recombinant CPS1 Monoclonal Antibody is available in 2 different pack sizes.

Is Recombinant CPS1 Monoclonal Antibody in stock?

Recombinant CPS1 Monoclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant CPS1 Monoclonal Antibody?

Recombinant CPS1 Monoclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for Recombinant CPS1 Monoclonal Antibody?

Estimated delivery time for Recombinant CPS1 Monoclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant CPS1 Monoclonal Antibody?

The safety data sheet for Recombinant CPS1 Monoclonal Antibody is available here: https://789.bio/eb/smiT9FrG.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.