Recombinant TBLR1/TBL1XR1 Monoclonal Antibody

Catalog number AN301924L-01

Choose a variant (2 options)

Selecting a variant updates its price, size and availability.

Price for AN301924L-01

Size / count 50 µL

Specifications

Catalog number: AN301924L-01
Size / count: 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: TBL1-related protein 1 (TBLR1/TBL1XR1) and Transducing β-like protein 1 (TBL1X/TBL1) were originally identified as subunits of the co-repressor silencing mediator for retinoic and thyroid hormone receptor (SMRT) and nuclear receptor co-repressor (NCoR) complexes. These two factors are required for the exchange of co-repressor complexes for co-activators by acting as adaptors to recruit the ubiquitin/proteasome machinery that degrades the co-repressor proteins during ligand mediated activation of transcription. Co-factor exchange driven by TBLR1/TBL1XR1 and TBL1X/TBL1 appears to be the mechanism by which c-Jun and NF-κB mediated transcription is activated and is therefore likely to be the mechanism employed by other signal-dependent transcription factors as well. In addition, both TBLR1/TBL1XR1 and TBL1X/TBL1 have essential roles in regulating the Wnt-signaling pathway by recruiting β-catenin to Wnt target genes to activate transcription. Depletion of TBLR1/TBL1XR1 significantly inhibited Wnt-beta-catenin- induced gene expression and oncogenic growth in vitro and in vivo. Research studies have shown that upregulation of TBLR1/TBL1XR1 is observed in a variety of solid tumors, and is correlated with advanced tumor stage, metastasis and poor prognosis.
Abbreviation: TBLR1/TBL1XR1
UniProt: Q9BZK7
Host: Rabbit
Reactivity: Human; Rat; Mouse
Immunogen: Recombinant human TBLR1/TBL1XR1 fragment
Target: MRD; IRA; TBLR; TBL1XR; TBL1XR1; C21; DC42; IRA1; MRD41; TBLR1
Clonality: Monoclonal, Recombinant
Clone: A640
Conjugation: Unconjugated
Applications: WB; IHC
Field of Research: Epigenetics and Nuclear Signaling; Cancer; Metabolism
Purification: Protein A purified
Concentration: 1 mg/mL
Dilution: WB 1:2000-1:5000; IHC 1:50-1:100
Buffer: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions: Ice bag
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 56 kDa
Observed Molecular Weight: 60 kDa
Isotype: IgG, κ

Frequently Asked Questions

What is the catalog number for Recombinant TBLR1/TBL1XR1 Monoclonal Antibody?

The catalog number for Recombinant TBLR1/TBL1XR1 Monoclonal Antibody is AN301924L.

What sizes are available for Recombinant TBLR1/TBL1XR1 Monoclonal Antibody?

Recombinant TBLR1/TBL1XR1 Monoclonal Antibody is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does Recombinant TBLR1/TBL1XR1 Monoclonal Antibody come in?

Recombinant TBLR1/TBL1XR1 Monoclonal Antibody is available in 2 different pack sizes.

Is Recombinant TBLR1/TBL1XR1 Monoclonal Antibody in stock?

Recombinant TBLR1/TBL1XR1 Monoclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant TBLR1/TBL1XR1 Monoclonal Antibody?

Recombinant TBLR1/TBL1XR1 Monoclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for Recombinant TBLR1/TBL1XR1 Monoclonal Antibody?

Estimated delivery time for Recombinant TBLR1/TBL1XR1 Monoclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant TBLR1/TBL1XR1 Monoclonal Antibody?

The safety data sheet for Recombinant TBLR1/TBL1XR1 Monoclonal Antibody is available here: https://789.bio/eb/8pfVCwLP.

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.