Recombinant Von Willebrand Factor Monoclonal Antibody

Specifications

Catalog number

AN301967L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

VWF (Von Willebrand factor) is a multimeric plasma glycoprotein that promotes adhesion of platelets to sites of vascular injury. Mature circulating VWF is made up of disulfide-bonded multimers that are in a complex with factor VIII. VWF is stored in secretory Weibel-Palade bodies in endothelial cells. It is synthesized as a large precursor protein and undergoes extensive posttranslational modifications including dimerization in the endoplasmic reticulum followed by cleavage of the pro-peptide and multimerization in the Golgi apparatus. VWF is important in hemostasis, and genetic defects in the structure and modification of VWF can cause von Willebrand disease (VWD), the most common congenital bleeding disorder in humans. Alternatively, increased levels of VWF have been shown to be involved in acute coronary thrombosis and are a clinical risk marker for atherosclerosis.

Abbreviation

Von Willebrand Factor

UniProt

Q8CIZ8

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Recombinant human Von Willebrand Factor fragment

Target

F8VWF; VWD; von Willebrand factor; von Willebrand antigen II; Vwf

Clonality

Monoclonal, Recombinant

Clone

A683

Conjugation

Unconjugated

Applications

WB; IHC

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:5000-1:10000; IHC 1:100-1:1000

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

309 kDa

Observed Molecular Weight

309 kDa

Isotype

IgG, κ