Recombinant Dopamine beta Hydroxylase Monoclonal Antibody

Specifications

Catalog number

AN301975L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Dopamine β-Hydroxylase (DBH) is an enzyme of the copper type II ascorbate-dependent mono-oxygenase family. This enzyme forms homotetramers composed of two noncovalently bound disulfide-linked dimers and is found as both membrane-associated and soluble forms. The soluble form is present in the lumen of secretory granules and is released from cells by exocytosis. DBH converts dopamine to noradrenaline. Deficiency in this enzyme causes a rare disease characterized by a complete absence of noradrenaline and adrenaline in plasma together with increased plasma dopamine levels. Orthostatic hypotension, the main symptom of DBH deficiency, can be alleviated by administration of dihydroxyphenylserine, a synthetic precursor of noradrenaline.

Abbreviation

Dopamine beta Hydroxylase

UniProt

P09172

Host

Rabbit

Reactivity

Human

Immunogen

Peptide. This information is proprietary to PTMab.

Target

OTTHUMP; DBH; DBM; Dopamine beta hydroxylase; Dopamine beta monooxygenase; Dopamine beta-hydroxylase (dopamine beta-monooxygenase) ; Dopamine beta-monooxygenase; DOPO; OTTHUMP00000022501; Soluble dopamine beta-hydroxylase; dopamine beta-hydroxylase; Dopamine β-hydroxylase

Clonality

Monoclonal, Recombinant

Clone

A691

Conjugation

Unconjugated

Applications

IHC

Field of Research

Neuroscience; Cancer; Metabolism

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

IHC 1:50-1:100

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG, κ