Recombinant SV2A Monoclonal Antibody

Specifications

Catalog number

AN301990L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

SV2s are a family of synaptic vesicle proteins expressed in both neurons and endocrine cells. SV2s function in the regulation of synaptic vesicle traffic, cytoplasmic Ca2+ levels in the nerve terminal during repetitive stimulation and the facilitation of synaptic transmission. There are three isoforms of SV2: SV2A, SV2B and SV2C. Each of these isoforms are structured similarly but expressed varyingly. SV2C, a minor isoform of SV2, expressed in a small subset of neurons located within the basal forebrain, midbrain and brainstem. SV2B, a major isoform of SV2 is expressed more abundantly, although rarely without the coexpression of SV2A. SV2A, the other major isoform of SV2 is the most widely expressed. SV2A is located in the presynaptic nerve terminals of almost every neuron throughout the nervous system. In addition, it is also located in most neuroendocrine secretory granules. SV2A has been identified as a critical protein for proper function of the central nervous system and has been linked to the physiopathology of epilepsy. In addition to the epileptic affects of this protein, mutations in it have also been seen to result in schizophrenia.

Abbreviation

SV2A

UniProt

Q7L0J3

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Recombinant fragment

Target

KIAA; PSEC; SV2; SV2A; KIAA0736; PSEC0174

Clonality

Monoclonal, Recombinant

Clone

A710

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Neuroscience

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:1000; IHC 1:500-1:1000

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

83 kDa

Observed Molecular Weight

100 kDa

Isotype

IgG, κ