Recombinant Tissue Plasminogen Activator Monoclonal Antibody

Specifications

Catalog number

AN302005L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Plasminogen activator, tissue (PLAT, synonyms: TPA, T-PA) is a tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein (33 kDa and 32 kDa) . PLAT enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. tPA has 4 isoforms produced by alternative splicing with the MW of 63 kDa, 33 kDa, 57 kDa and 44 kDa.

Abbreviation

Tissue Plasminogen Activator

UniProt

P00750

Host

Rabbit

Reactivity

Human; Rat

Immunogen

Peptide. This information is proprietary to PTMab.

Target

PLAT; T-PA; TPA; Tissue plasminogen activator; t-plasminogen activator; Alteplase; DKFZp686I03148; Plasminogen activator tissue; Plasminogen activator tissue type; Reteplase; t PA; T Plasminogen Activator; Tissue plasminogen activator (t PA) ; Tissue type plasminogen activator; Tissue-type plasminogen activator chain B; TPA1

Clonality

Monoclonal, Recombinant

Clone

A725

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cardiovascular; Cell Biology; Cancer; Metabolism

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:1000; IHC 1:500-1:1000

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

63 kDa

Observed Molecular Weight

55 kDa

Isotype

IgG, κ