Recombinant WT1 Monoclonal Antibody

Specifications

Catalog number

AN302022L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Wilms' Tumor protein (WT1) is a transcription factor named from Wilms' Tumor 1, an embryonal malignancy of the kidneys that is caused by mutations in the WT1 gene. It is highly important in development, particularly of the genitourinary system, and mutations and dysregulation of expression of WT1 result in a variety of syndromes affecting the genitourinary system and other tissues.WT1 has a myriad of biological functions and a host of interacting partners and target genes. It can behave as a transcriptional activator, or a repressor, and can act as an oncogene or a tumor suppressor. It exerts influence over the epigenetic landscape, and also has post translational influence of gene expression through RNA interactions. The diverse biological roles of WT1 have been attributed to the existence of multiple isoforms and post translation modifications of the protein.

Abbreviation

WT1

UniProt

P19544

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Peptide. This information is proprietary to PTMab.

Target

AWT; FWT; NPHS; EWS-WT; WIT; WT1; AWT1; EWS-WT1; GUD; NPHS4; WAGR; WIT-2; WT33; FWT1; Wilms Tumor; Wilms tumor 1; Wilms' tumor gene; Wilms tumor protein; Wilms' tumor protein; WIT 2; WIT2; WT; WT 1; WIT 2; WT 1; AWT1; FWT1; GUD; NPHS4; WAGR; Wilms tumor 1; Wilms Tumor; Wilms tumor protein; Wilms' tumor gene; Wilms' tumor protein; WIT2; WT; WT1; WT1; WT33

Clonality

Monoclonal, Recombinant

Clone

A742

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Tags & Cell Markers; Epigenetics and Nuclear Signaling; Cancer; Developmental Biology

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:2000-1:10000; IHC 1:100

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

49 kDa

Observed Molecular Weight

52 kDa

Isotype

IgG, κ