Recombinant Prealbumin/Transthyretin Monoclonal Antibody

Specifications

Catalog number

AN302048L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Transthyretin (TTR) is a highly conserved homotetremric protein that is synthesized in the liver and choroid plexus of the brain. TTR wasoriginally discovered as a protein found in human plasma and cerebrospinal fluid (CSF) . TTR transports thyroid hormones (TH) and retinol bybinding to retinol-binding protein. Although TTR is synthesized in the liver and choroid plexus, TTR is detected in blood plasma andcerebrospinal fluid migrating as monomers, dimers, and tetramers. Beyond its function as a carrier protein of TH and retinol in plasma andCSF, several additional TTR functions have been described, including proteolytic cleavage of specific substrates like apolipoprotein, neuropeptide Y (NPY), and APP. These neuronal substrates suggest a functional role for TTR in the central nervous system. Consistent witha CNS function, TTR null mice exhibit memory impairments and altered sensorimotor behavior) . TTR may also be linked to neurodegenerativedisease: TTR levels in Alzheimer’s disease (AD) patients are negatively correlated with disease progression, and a protective role for TTR, atleast in AD mouse models, has been described. TTR itself may play a more direct role in disease as gain-of-function mutations in TTR causethe protein to misfold and aggregate into amyloid fibrils, contributing to autosomal dominant hereditary amyloidosis in diseases such as familialamyloid polyneuropathy, familial amyloid cardiomyopathy, and familial leptomeningeal amyloidosis.

Abbreviation

Prealbumin/Transthyretin

UniProt

P02766

Host

Rabbit

Reactivity

Human

Immunogen

Peptide. This information is proprietary to PTMab.

Target

HEL; HsT; TTR; CTS; CTS1; HEL111; HsT2651; PALB; TBPA; ATTR; Prealbumin; Transthyretin; Amyloid polyneuropathy; Amyloidosis I; Carpal tunnel syndrome 1; Dysprealbuminemic euthyroidal hyperthyroxinemia; Dystransthyretinemic hyperthyroxinemia; Epididymis luminal protein 111; Prealbumin amyloidosis type I; Prealbumin Thyroxine-binding; Senile systemic amyloidosis; Thyroxine binding prealbumin; Transthyretin; TTR; TTHY; TTR protein

Clonality

Monoclonal, Recombinant

Clone

A768

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Neuroscience; Cardiovascular

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:1000; IHC 1:1000

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

16 kDa

Observed Molecular Weight

35 kDa

Isotype

IgG, κ