Recombinant RBBP7/RBBP4 Monoclonal Antibody

Specifications

Catalog number

AN302067L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Retinoblastoma-associated proteins 46 and 48 (RBAP46 and RBAP48, also known as RBBP7 and RBBP4), were first identified in humancells as proteins that bind to retinoblastoma (Rb) tumor suppressor proteins. Since then, these proteins have been shown to be componentsof a number of protein complexes involved in chromatin regulation, including the chromatin assembly factor 1 (CAF-1) complex and the Btype histone acetyltransferase complex, HAT1, both of which are involved in chromatin assembly during DNA replication. RBAP46 andRBAP48 are also present in the nucleosome remodeling factor complex, NURF, and the nucleosome remodeling and histone deacetylationcomplex NuRD, and the Sin3/HDAC histone deacetylation complex. Recently, RBAP46 and RBAP48 were identified as components of thepolyribonucleic acid repressor complex PRC2, which also contains EED and Ezh2. RBAP46 and RBAP48 bind to the histone folding regionof histone H4 and are thought to target these chromatin remodeling, histone acetylation and histone deacetylation complexes to their histonesubstrates.

Abbreviation

RBBP7/RBBP4

UniProt

Q16576; Q09028

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Peptide. This information is proprietary to PTMab.

Target

RBAP46; RBAP48

Clonality

Monoclonal, Recombinant

Clone

A787

Conjugation

Unconjugated

Applications

WB; IHC; FCM; ChIP; IP

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

6

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

48 kDa

Observed Molecular Weight

50 kDa

Isotype

IgG, κ