Recombinant Phospho-IKB alpha (Ser32, Ser36) Monoclonal Antibody

Specifications

Catalog number

AN302083L-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

NF-kappa-B inhibitor alpha (IKB alpha) inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, IKB alpha becomes phosphorylated promoting itself ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Abbreviation

Phospho-IKB alpha (Ser32, Ser36)

UniProt

P25963

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Recombinant human IKB alpha (phospho S32/36) fragment

Target

EDAID; MAD; IKBA; MAD-3; NFKBI; IKB alpha; NFKBIA; EDAID2; I kappa B alpha; IkappaBalpha; I-kappa-B-alpha; IKBalpha; IkB-alpha; MAD 3; NF kappa B inhibitor alpha; MAD3; alpha; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappa-B inhibitor alpha; Nuclear factor of kappa light chain gene enhancer in B cells; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor; pIκBα

Clonality

Monoclonal, Recombinant

Clone

A807

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Immunology

Purification

Protein A purified

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:100

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

36 kDa

Observed Molecular Weight

36 kDa

Isotype

IgG, κ