Aquaporin 4 Recombinant Rabbit Monoclonal Antibody [PSH06-38]

About this product

Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. AQP-4 belongs to the aquaporin family of integral membrane proteins that conduct water through the cell membrane. A limited number of aquaporins are found within the central nervous system (CNS): AQP1, 3, 4, 5, 8, 9, and 11, but more exclusive representation of AQP1, 4, and 9 are found in the brain and spinal cord. AQP4 shows the largest presence in the cerebellum and spinal cord grey matter. In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. In addition, this channel is commonly found facilitating water movement near cerebrospinal fluid and vasculature. Aquaporin-4 was first identified in 1986. It was the first evidence of the existence of water transport channels. The method that was used to discover the existence of the transport channels was through knockout experiments. With this technique they were able to show the significant role of AQP4 in CNS injuries and brain water imbalances. In 1994 the channel was successfully cloned and initially named Mercury-Insensitive Water Channel.

Specifications

Catalog number

HA722672

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AQP 4 antibody AQP-4 antibody AQP4 antibody AQP4_HUMAN antibody Aquaporin type 4 antibody Aquaporin-4 antibody Aquaporin4 antibody HMIWC 2 antibody HMIWC2 antibody Mercurial insensitive water channel antibody Mercurial-insensitive water channel antibody MGC22454 antibody MIWC antibody WCH 4 antibody WCH4 antibody

Abbreviation

AQP4

Swiss Prot

P55087 Human, P55088 Mouse, P47863 Rat

Cellular Locus

Cell membrane, Basolateral cell membrane, Endosome membrane, Cell membrane, sarcolemma, Cell projection.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human 224-323.

Isotype

IgG

Clone

PSH06-38

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Tissue, IHC-Fr, IP

Positive Control

Mouse brain tissue lysate, Rat brain tissue lysate, mouse brain tissue, rat brain tissue, human kidney tissue, human brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IHC-P: 1:2,000-1:10,000 ;IF-Tissue: 1:200 ;IHC-Fr: 1:200 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 35 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes