IDO1 Polyclonal Antibody

Specifications

Catalog number

D-AB-10451L-01

Size / count

25 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. This protein is normally expressed in the dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumor cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumor cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumor associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression.

Abbreviation

IDO1

UniProt

P14902

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human IDO1 protein expressed by E.coli

Target

Indole 2;3-dioxygenase; Indoleamine 2;3-dioxygenase 1; IDO-1; IDO1; IDO; INDO

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cardiovascular; Metabolism; Signal Transduction

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

IHC 1:150-1:300

Buffer

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG