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Product details
Catalog number H10033.25G
Price for H10033.25G
Size / count 25 g
A very acid sensitive resin suitable for the synthesis of protected peptide fragments by the Fmoc strategy. In particular suitable for the preparation of C-terminal prolyl and cysteinyl peptides. Cleavage from this resin is achieved by using 1-95% TFA in DCM (containing 8% triisopropylsilane), AcOH/CF3OH/DCM, 0.5% TFA or hexafluoroisopropanol. Recently, this resin has been used in cyclization reactions under Heck reaction conditions, the solid phase synthesis of ß-peptides via the Arndt-Eistert homologation of Fmoc-protected amino acid diazoketones and in Mannich reactions of alkynes, secondary amines and aldehydes in the presence of a copper (I) salt leading to the corresponding aminomethyl alkynyl adducts.This resin can also be used in Fmoc peptide synthesis. Carboxylic acids can be released under very mild acidic conditions by treatment with AcOH/TFE/DCM or HFIP in DCM. Completely protected peptides are generated under these conditions. This resin is less sensitive towards acids compared to chlorotrityl resins. Coupling of the first amino acid is not carried out by activation, thus enantiomerization does not occur.
The catalog number for Chloro- (2'-chloro) trityl Polystyrene is H10033.25G.
Chloro- (2'-chloro) trityl Polystyrene is available in the following size(s): 25 g.
Chloro- (2'-chloro) trityl Polystyrene is currently made to order / not held in immediate stock. Contact us for lead time.
A very acid sensitive resin suitable for the synthesis of protected peptide fragments by the Fmoc strategy. In particular suitable for the preparation of C-terminal prolyl and cysteinyl peptides. Cleavage from this resin is achieved by using 1-95% TFA in DCM (containing 8% triisopropylsilane), AcOH/
Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.
A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.
Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.
