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Product details
Catalog number H25031533.100G
Price for H25031533.100G
Size / count 100 g
A very acid sensitive resin suitable for the synthesis of protected peptide fragments by the Fmoc strategy. In particular suitable for the preparation of C-terminal prolyl and cysteinyl peptides. Cleavage from this resin is achieved by using 1-95% TFA in DCM (containing 8% triisopropylsilane), AcOH/CF3OH/DCM, 0.5% TFA or hexafluoroisopropanol. Recently, this resin has been used in cyclization reactions under Heck reaction conditions, the solid phase synthesis of ß-peptides via the Arndt-Eistert homologation of Fmoc-protected amino acid diazoketones and in Mannich reactions of alkynes, secondary amines and aldehydes in the presence of a copper (I) salt leading to the corresponding aminomethyl alkynyl adducts.This resin can also be used in Fmoc peptide synthesis. Carboxylic acids can be released under very mild acidic conditions by treatment with AcOH/TFE/DCM or HFIP in DCM. Completely protected peptides are generated under these conditions. This resin is less sensitive towards acids compared to chlorotrityl resins. Coupling of the first amino acid is not carried out by activation, thus enantiomerization does not occur.
The catalog number for Chloro- (2'-chloro) trityl Polystyrene is H25031533.100G.
Chloro- (2'-chloro) trityl Polystyrene is available in the following size(s): 100 g.
Chloro- (2'-chloro) trityl Polystyrene is currently made to order / not held in immediate stock. Contact us for lead time.
A very acid sensitive resin suitable for the synthesis of protected peptide fragments by the Fmoc strategy. In particular suitable for the preparation of C-terminal prolyl and cysteinyl peptides. Cleavage from this resin is achieved by using 1-95% TFA in DCM (containing 8% triisopropylsilane), AcOH/
Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.
A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.
Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.
