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Product details
Catalog number 135000-00-50.1G
Price for 135000-00-50.1G
Size / count 1 g
PEGs with an active ester functional group at one end allow for selective and covalent attachment to other molecules with complementary functional groups, such as primary amines on proteins, peptides, or other molecules. To a lesser extent they are reactive towards thiols or hydroxyls (to form thioesters or esters) . Squaric Acid Ester Amido PEGs are a novel class of reactive and chemoselective PEG crosslinking reagents. The squaric acid PEGs are chemoselective towards the amino groups of Lysin in protein PEGylation whereas the guanidine function of Arginine, the hydroxyl group of Serine and the imidazole function of Histidine are not affected. Compared to other active esters, these PEGs are remarkably stable in aqueous media and not easily hydrolyzed. The hydroxy group on one side of this PEG crosslinker is able to undergo esterification reactions with acids for reversible pegylation. It also enables further derivatization or replacement with other reactive functional groups.
The catalog number for Ɑ-Hydroxy-ω-Squaric Acid Ester Amido PEG is 135000-00-50.1G.
Ɑ-Hydroxy-ω-Squaric Acid Ester Amido PEG is available in the following size(s): 1 g.
Ɑ-Hydroxy-ω-Squaric Acid Ester Amido PEG is currently made to order / not held in immediate stock. Contact us for lead time.
PEGs with an active ester functional group at one end allow for selective and covalent attachment to other molecules with complementary functional groups, such as primary amines on proteins, peptides, or other molecules. To a lesser extent they are reactive towards thiols or hydroxyls (to form thioe
Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.
Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.
A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.
