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Product details
Catalog number 135000-22-35.500MG
Price for 135000-22-35.500MG
Size / count 500 mg
PEG crosslinkers with Fmoc (fluorenylmethoxycarbonyl) -protected amino groups on one chain end. The Fmoc protecting group is stable in a wide range of conditions (including highly acidic environments) but may be easily removed by primary and secondary amine bases (such as piperidine) in polar solvents to release the primary amine. The amine functional group at one end of the PEG linker molecule allows for selective and covalent attachment to other molecules with complementary functional groups, such as carboxylic acids or activated esters, aldehydes and epoxides. The newly formed bonds are amides, imines or secondary amines. Applicable for reversible or permanent crosslinking with PEG. PEG-NHS derivatives are active esters and useful reagents to pegylate proteines, peptides or any other surfaces with a free primary amino group to form stable amide bonds. The Reaction requires a neutral to alkaline pH (7 to 8.5) to proceed. However, hydrolysis competes with aminolysis of the active ester and also increases with higher pH. Thus, working with excess PEG-NHS is necessary to obtain high pegylation yields. The PEG butyric acid NHS ester derivative has a C4 chain directly attached to PEG and the NHS active ester group. It is one of the most stable PEG NHS esters known with a hydrolysis half-life of over 20 min at pH 8.
The catalog number for Ɑ-Butyric Acid NHS Ester-ω-Fmoc Amino PEG is 135000-22-35.500MG.
Ɑ-Butyric Acid NHS Ester-ω-Fmoc Amino PEG is available in the following size(s): 500 mg.
Ɑ-Butyric Acid NHS Ester-ω-Fmoc Amino PEG is currently made to order / not held in immediate stock. Contact us for lead time.
PEG crosslinkers with Fmoc (fluorenylmethoxycarbonyl) -protected amino groups on one chain end. The Fmoc protecting group is stable in a wide range of conditions (including highly acidic environments) but may be easily removed by primary and secondary amine bases (such as piperidine) in polar solven
Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.
Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.
No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.
