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Product details
Catalog number 135000-65-32.500MG
Price for 135000-65-32.500MG
Size / count 500 mg
This PEG linker with a maleimide endgroup is applied in sulfhydryl-selective coupling of PEG to proteins and other thiol substrates and for selective scavenging of thiol containing peptides. The maleimide group reacts at about neutral pH with free thiols via a Michael addition to form a stable thioether bond. Carboxy PEGs may be used for conjugation to amine substrates (forming amides) or other nucleophiles (forming esters) . However, activation is necessary prior to conjugation. Different PEG carboxy derivatives display a different degree of stability and reactivity of the corresponding active ester. The butyric acid endgroup is directly connected to the PEG chain via a very stable ether linkage. After activation it is used to conjugate the PEG derivative to nucleophilic substrates, mainly amines (to form amides) or hydroxyls/thiols (forming esters) . PEG butyric acid active esters are one of the most hydrolytically stable PEG active esters. They can be used for pegylation in aqueous media without the need of a large excess of PEG.
The catalog number for Ɑ-Butyric Acid-ω-Maleimidohexanamido PEG is 135000-65-32.500MG.
Ɑ-Butyric Acid-ω-Maleimidohexanamido PEG is available in the following size(s): 500 mg.
Ɑ-Butyric Acid-ω-Maleimidohexanamido PEG is currently made to order / not held in immediate stock. Contact us for lead time.
This PEG linker with a maleimide endgroup is applied in sulfhydryl-selective coupling of PEG to proteins and other thiol substrates and for selective scavenging of thiol containing peptides. The maleimide group reacts at about neutral pH with free thiols via a Michael addition to form a stable thioe
Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.
Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.
Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.
